8 research outputs found

    Man-Computer Problem Solving in Real-Time Naval Duels

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    The development of a new Man-Computer Problem Solving Methodology to be widely and effectively applied by the Navy has been the objective of this Research Project. The basic hypothesis that has been examined is as follows. If an interactive system would be available by which a human problem solver could put together, easily and quickly, a simulation of the problem and quickly perform tests of various solutions, perform an evaluation and then further improve the solution, then large scale economies and improved effectiveness would result. The research reported here may be considered to having taken the empirical approach. An experimental environment was selected, namely a Naval War. An interactive problem solving computer system was designed for this environment. To obtain an indication of the effectiveness of the system required the solution of problems in human engineering, computational methods and strategy in the areas of tracking and navigation, sonar applications and processing, and weapon application. New real-time interactive systems were incorporated to simplify the evolution of new problem solving methodologies

    GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo.

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    We previously demonstrated that the zinc finger transcription factors GATA-2 and GATA-3 are expressed in trophoblast giant cells and that they regulate transcription from the mouse placental lactogen I gene promoter in a transfected trophoblast cell line. We present evidence here that both of these factors regulate transcription of the placental lactogen I gene, as well as the related proliferin gene, in trophoblast giant cells in vivo. Placentas lacking GATA-3 accumulate placental lactogen I and proliferi

    Crustal structure of the carpathian-pannonian region from ambient noise tomography

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    We use ambient noise tomography to investigate the crust and uppermost mantle structure beneath the Carpathian-Pannonian region of Central Europe. Over 7500 Rayleigh wave empirical Green's functions are derived from interstation cross-correlations of vertical component ambient seismic noise recordings (2005-2011) using a temporary network of 54 stations deployed during the South Carpathian Project (2009-2011), 56 temporary stations deployed in the Carpathian Basins Project (2005-2007) and 100 permanent and regional broad-band stations. Rayleigh wave group velocity dispersion curves (4-40 s) are determined using the multiple-filter analysis technique. Group velocity maps are computed on a grid of 0.2° × 0.2° from a non-linear 2-D tomographic inversion using the subspace method. We then inverted the group velocity maps for the 3-D shear wave velocity structure of the crust and uppermost mantle beneath the region. Our shear wave velocity model provides a uniquely complete and relatively high-resolution view of the crustal structure in the Carpathian-Pannonian region, which in general is validated by comparison with previous studies using other methods to probe the crustal structure. At shallow depths (30 km are relatively fast, presumably related to shallowing of the Moho consequent on the extensional history of the Pannonian region

    Inhibition of cell wall biosynthesis by analogues of alanine

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    Life-Threatening and Non-Life-Threatening Complications Associated With Coughing

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